Rome, Italy, October 11-14, 2023
Conference Program
Wednesday, October 11, 2023
17:00-18:00: Registration
18:00-20:00: Welcome Faculty Meeting
Thursday, October 12, 2023
8:50-9:00: Opening Remarks
Carmine Cardillo, Catholic University of the Sacred Heart, Rome, Italy
Neeraj Dhaun, University of Edimburgh, Edimburgh, UK
Francesca Schinzari, Policlinico Gemelli IRCCS, Rome, Italy
9:00-9:30 Opening Lecture:
Recent advances in drugs acting on the ET-1 system
Anthony Davenport, University of Cambridge, Cambridge, UK
9:30-11:10: Morning Session 1: ET-1 targeting in oncology
Chairs:
Pedro D’Orleans-Juste, Université de Sherbrooke, Sherbrooke, Canada
Janet Maguire, University of Cambridge, Cambridge, UK
9:30-10:00 KeyNote Lecture:
Role of the endothelin system in cancer-supporting phenotypic alterations
Rajkumar Savai, Liebig University, Giessen, Germany
10:00-10:15 Selected oral presentation
10:15-10:30 Selected oral presentation
10-30-10:45 Selected oral presentation
10:45-11:10 Invited Lecture:
Identification of new therapeutic vulnerabilities in cancer exploiting the molecular ET-averse
Anna Bagnato, Regina Elena National Cancer Institute, Rome, Italy
11:10-11:30 Coffee break
11:30-13:15 Morning Session 2: Endothelin antagonism in hypertension
Chairs:
David Webb, The Queen Medical’s Research Institute, Edinburgh, Scotland
Ivana Vaneckova, Czech Academy of Sciences, Prague, Czech Republic
11:30-12:00 KeyNote Lecture:
Non-selective ET receptor antagonism in resistant hypertension: the PRECISION trial
Ernesto Schiffrin, McGill University, Montreal, Canada
12:00-12:15 Selected oral presentation
12:15:12:30 Selected oral presentation
12:30:12:45 Selected oral presentation
12:45-13:15 Special Lecture
Nitric oxide
Louis J. Ignarro, UCLA, Nobel Prize in Physiology or Medicine 1998
13:15-14:00 Lunch
14:00-15:00 Poster Session 1
Chairs:
Jennifer Pollock, University of Alabama, Birmingham, USA
Michelle Gumz, University of Florida, Gainesville, USA
15:00-16:45 Afternoon Session 1: Endothelin-1 and neurological disorders
Chairs:
Rita Tostes, University of Sao Paulo, Sao Paulo, Brazil
Kelly Hyndman, University of Alabama at Birmingham, Birmingham, USA
15:00-15:30 KeyNote Lecture:
Effects of endothelin-1 on the brain microvasculature
Adviye Ergul, Medical University of South Carolina, Charleston, USA:
15:30-15:45 Selected oral presentation
15:45-16:00 Selected oral presentation
16:00-16:15 Selected oral presentation
16:15-16:45 Invited Lecture:
Advances in the treatment of neurologic disorders using drugs active on the endothelin system
Anil Gulati, Midwestern University of Illinois, Chicago, USA
Friday October 13, 2023
9:00-11:00: Morning Session 3: Recent acquisitions in the treatment of kidney disease
Chairs:
Ariela Benigni, Mario Negri Institute, Bergamo, Italy
David Pollock, University of Alabama, Birmingham, USA
9:00-9:30 KeyNote Lecture:
Review of recent clinical trials with drugs targeting the ET-1 system
Hiddo Lambers Heerspink, University Medical Center, Groningen, The Netherlands
9:30-9:45 Selected oral presentation
9:45-10:00 Selected oral presentation
10:00-10:15 Selected oral presentation
10:15-10:45 Invited Lecture:
Is there a role of ET antagonism for nephroprotection in the era of SGLT2 or mineralcorticoid receptor inhibition?
Pierre-Louis Tharaux, Centre de Recherche Cardiovasculaire, Paris, France
10:45-11:05 Coffee break
11:20-13:15 Morning Session 4: Cardiology
Chairs:
John Pernow, Karolinska Institutet, Stockolm, Sweden
Rajat Gupta, Harvard Medical School, Boston, U.S.A.
11:05-11: 35 KeyNote Lecture:
Could targeting the endothelin system become a suitable approach in HFpEF?
Kieran Daugherty, University of Glasgow, Glasgow, Scotland
11:35-11:50 Selected oral presentation
11:50-12:05 Selected oral presentation
12:05-12:20 Selected oral presentation
12:20-12:55 Invited Lecture:
Endothelin in coronary artery diseases
Matthias Barton, University of Zurich, Zurich, Switzerland
12:55-13:15 Invited Lecture:
Mandibulofacial dysostosis with alopecia resulting from ETAR gain-of-function
Y. Kurihara, Unviersity of Tokyo, Tokyo, Japan
13:15-14:00 Lunch
14:00-15:00 Poster Session 2
Chairs:
Ivana Vaneckova, Czech Academy of Sciences, Prague, Czech Republic
Kelly Hyndman, University of Alabama, Birmingham, U.S.A.
15:00-16:45 Afternoon Session 2: Endocrinology and Metabolism
Chairs:
Manfredi Tesauro, Tor Vergata University, Rome, Italy
Jo De Mey, University of Maastricht, Maastricht, Netherlands
15:00-15:30 KeyNote Lecture:
Role of ET-1 in the oxidative stress associated with diabetic vasculopathy
Rhian Touyz, McGill University, Montreal, Canada
15:30-15:45 Selected oral presentation
15:45-16:00 Selected oral presentation
16:00-16:15 Selected oral presentation
16:15-16:45 Invited Lecture:
Role of endothelin and endothelin antagonism in non-alcoholic fatty liver degeneration (NALFD)
Wilhelmus Kwanten, University of Antwerp, Antwerp, Belgium
Saturday October 14, 2023
9:00-10:45: Morning Session 5: Pulmonology and Rheumatology
Chairs:
Pedro D’Orleans-Juste University of Sherbrooke, Sherbrooke, Canada
Carmine Cardillo, Catholic University, Rome, Italy
9:00-9:30 KeyNote Lecture:
Update on the use of ET-1 antagonists in pulmonary hypertension
Noriaki Emoto. Kobe Pharmaceutical University, Kobe, Japan:
9:30-9:45 Selected oral presentation
9:45-10:00 Selected oral presentation
10:00-10:15 Selected oral presentation
10:15-10:45 Invited Lecture:
Role of ET-1 in vasculitis
Neeraj Dhaun, University of Edinburgh, Edinburgh, Scotland
10:45-11:05 Coffee Break
11:05-12:50 Morning Session 6: Dermatology and Women's Health
Chairs:
Matthias Barton, University of Zurich, Zurich, Switzerland
Donald Kohan University of Utah, Salt Lake City, USA
11:05-11:35 KeyNote Lecture:
ET-1 and hair follicle regeneration
Michael Rendl, Icahn School of Medicine at Mount Sinai, New York, USA
11:35-11:50 Selected oral presentation
11:50-12:05 Selected oral presentation
12:05-12:20 Selected oral presentation
12:20-12:50 Invited Lecture:
Role of ET-1 in pre-eclampsia
Jan Danser, Erasmus University, Rotterdam, The Netherlands:
12:50-13:35 Lunch
13:35-14:45 Round Table: Endothelin targeting: where are we going?
Donald Kohan, University of Utah, Salt Lake City, Utah, USA, Moderator and Chair
Introduction
Panelists: TBD
14:45-15:15 Award Ceremony
15:15-15:45 ET-18 Highlights
Masashi Yanagisawa, University of Tsukuba, Tsukuba, Japan
15:45-16:00 Closing remarks of the Conference Chairs